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Organometallic compounds, complexes bearing a M-C bond, constitute a highly important class that find uses in a multitude of areas. Various globally significant applications, for example, developing new drugs for medicinal chemistry can attribute their huge success to the diversity of ancillary ligands that can be incorporated to access libraries of organometallic compounds possessing similar structural features. We have been interested, for many years, in studying the chemistry of various organometallic compounds based primarily on late transition metals such as ruthenium, rhodium, iridium, palladium, and platinum to name but a few. Ideal spectator ligands, complimentary to those aforementioned target metals, often include specific Group 15 donor atoms incorporating nitrogen or phosphorus centres that can firmly anchor these metal centres. In this exciting project, we will use synthetic methodologies developed in our research group to prepare novel families of (i) New fluorescent Schiff base chelating ligands and (ii) Preorganised fluorescent diphosphane ligands with unique bridging capabilities for anchoring two organometallic metal centres. Once synthesised and characterised, these compounds will be systematically evaluated for their cytotoxic properties. This project will provide an excellent training opportunity, for a prospective PhD candidate, in modern well-equipped laboratories with access to multinuclear NMR facilities, X-ray crystallography, fluorescence spectroscopy, elemental imaging and bio lab testing facilities.
Programme overview
Main Subject
Chemistry
Degree
PhD
Study Level
PHD
Study Mode
On Campus
Organometallic compounds, complexes bearing a M-C bond, constitute a highly important class that find uses in a multitude of areas. Various globally significant applications, for example, developing new drugs for medicinal chemistry can attribute their huge success to the diversity of ancillary ligands that can be incorporated to access libraries of organometallic compounds possessing similar structural features. We have been interested, for many years, in studying the chemistry of various organometallic compounds based primarily on late transition metals such as ruthenium, rhodium, iridium, palladium, and platinum to name but a few. Ideal spectator ligands, complimentary to those aforementioned target metals, often include specific Group 15 donor atoms incorporating nitrogen or phosphorus centres that can firmly anchor these metal centres. In this exciting project, we will use synthetic methodologies developed in our research group to prepare novel families of (i) New fluorescent Schiff base chelating ligands and (ii) Preorganised fluorescent diphosphane ligands with unique bridging capabilities for anchoring two organometallic metal centres. Once synthesised and characterised, these compounds will be systematically evaluated for their cytotoxic properties. This project will provide an excellent training opportunity, for a prospective PhD candidate, in modern well-equipped laboratories with access to multinuclear NMR facilities, X-ray crystallography, fluorescence spectroscopy, elemental imaging and bio lab testing facilities.
Admission Requirements
3.2+
6.5+
92+
30 Sep 2025
3 Years
Apr
Jul
Domestic
4,786
International
27,500
Scholarships
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Bespoke Organometallic Compounds for Anticancer Studies PhD
Loughborough University, Loughborough, United Kingdom
# 301-350QS Subject Rankings
36 monthsProgramme duration
27,500 Tuition Fee/year
30 Sep, 2025Application Deadline
Programme overview
Main Subject
Chemistry
Degree
PhD
Study Level
PHD
Study Mode
On Campus
We have been interested, for many years, in studying the chemistry of various organometallic compounds based primarily on late transition metals such as ruthenium, rhodium, iridium, palladium, and platinum to name but a few. Ideal spectator ligands, complimentary to those aforementioned target metals, often include specific Group 15 donor atoms incorporating nitrogen or phosphorus centres that can firmly anchor these metal centres.
In this exciting project, we will use synthetic methodologies developed in our research group to prepare novel families of (i) New fluorescent Schiff base chelating ligands and (ii) Preorganised fluorescent diphosphane ligands with unique bridging capabilities for anchoring two organometallic metal centres. Once synthesised and characterised, these compounds will be systematically evaluated for their cytotoxic properties.
This project will provide an excellent training opportunity, for a prospective PhD candidate, in modern well-equipped laboratories with access to multinuclear NMR facilities, X-ray crystallography, fluorescence spectroscopy, elemental imaging and bio lab testing facilities.
Programme overview
Main Subject
Chemistry
Degree
PhD
Study Level
PHD
Study Mode
On Campus
We have been interested, for many years, in studying the chemistry of various organometallic compounds based primarily on late transition metals such as ruthenium, rhodium, iridium, palladium, and platinum to name but a few. Ideal spectator ligands, complimentary to those aforementioned target metals, often include specific Group 15 donor atoms incorporating nitrogen or phosphorus centres that can firmly anchor these metal centres.
In this exciting project, we will use synthetic methodologies developed in our research group to prepare novel families of (i) New fluorescent Schiff base chelating ligands and (ii) Preorganised fluorescent diphosphane ligands with unique bridging capabilities for anchoring two organometallic metal centres. Once synthesised and characterised, these compounds will be systematically evaluated for their cytotoxic properties.
This project will provide an excellent training opportunity, for a prospective PhD candidate, in modern well-equipped laboratories with access to multinuclear NMR facilities, X-ray crystallography, fluorescence spectroscopy, elemental imaging and bio lab testing facilities.
Admission Requirements
Domestic
International
Scholarships
Selecting the right scholarship can be a daunting process. With countless options available, students often find themselves overwhelmed and confused. The decision can be especially stressful for those facing financial constraints or pursuing specific academic or career goals.
To help students navigate this challenging process, we recommend the following articles:
How to get a full scholarship
Looking for a fully-funded scholarship to see you into university? Find out how to boost your chances of getting one.
Scholarships to study abroad
Find scholarships to study abroad with our lists of international scholarships – categorized by country, by subject, and by type of student.
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Engineering New Materials for Solid-State Cooling Phd
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Unveiling Molecular Mechanisms of the Beneficial Impact of Exercise on Cancer Metabolism PhD
Using the Metabolome to Study Aging and Geroprotectors in 3D Cell Models PhD
Visual Data Mining on Proteins and Biomedicine Crystallisation PhD
Waste-derived Bioplastics for a Circular and Sustainable Food Packaging Economy PhD
Life Sciences and Medicine (6)
Adaptive and Predictive Computational Modelling of Biomaterials: A Digital Twin Framework for Next-Generation Personalised Healthcare PhD
Adaptive and Predictive Computational Modelling of Biomaterials: A Digital Twin Framework for Next-Generation Personalised Healthcare PhD
Biomarkers of Aging PhD
Biomarkers of Aging PhD
Developing Prescription Guidelines for Passive Heat Therapy PhD
Developing Prescription Guidelines for Passive Heat Therapy PhD
Does Socialised Real-Life Body Exposure Promote Body Image Positivity PhD
Does Socialised Real-Life Body Exposure Promote Body Image Positivity PhD
Energy Dissipation In Human Soft Tissue During Impacts PhD
Energy Dissipation In Human Soft Tissue During Impacts PhD
Natural Sciences (6)
Accelerated Screening and Synthesis of New Chemotherapeutic Agents for Pancreatic Cancer PhD
Accelerated Screening and Synthesis of New Chemotherapeutic Agents for Pancreatic Cancer PhD
Bespoke Organometallic Compounds for Anticancer Studies PhD
Bespoke Organometallic Compounds for Anticancer Studies PhD
Bio-based Sustainable Materials for Autonomous Thermal Management in Wearables PhD
Bio-based Sustainable Materials for Autonomous Thermal Management in Wearables PhD
Biomimmetic Catalytic Asymmetric Synthesis of the Bisorbicillinoids and Related Products PhD
Biomimmetic Catalytic Asymmetric Synthesis of the Bisorbicillinoids and Related Products PhD
Climate and Ecological Transitions Hub Studentship PhD
Climate and Ecological Transitions Hub Studentship PhD
Coherent State Methods in Spectral Asymptotics PhD
Coherent State Methods in Spectral Asymptotics PhD
Computational Modelling of Sustainable Alloys PhD
Designing Classroom Tasks To Improve Students’ Learning Of Mathematics PhD
Developing Novel Antibiofilm Coatings for Sustainable Biofilm-Free Surfaces PhD
Development of Hybrid Microcomb Sources with Topologically Protected Dark Resonances for Simultaneous Classical and Quantum PhD
Development of Novel Bicyclopentanes (BCP) Bioisosteres From Bench Stable [1.1.1]-Propellane Precursors PhD
Digital Twins for Biofilm Management PhD
Dispersionless Integrable Systems In 2+1 Dimensions PhD
Social Sciences and Management (6)
An Evaluation of Erasmus+ Sport Projects and Their Impact on EU Sport Policy Development PhD
An Evaluation of Erasmus+ Sport Projects and Their Impact on EU Sport Policy Development PhD
Climate Change, Work Design and Worker Wellbeing Phd
Climate Change, Work Design and Worker Wellbeing Phd
Communication and Social Change (CSC) Hub Studentship PhD
Communication and Social Change (CSC) Hub Studentship PhD
Enhancing Motivation in Sport and Exercise Contexts PhD
Enhancing Motivation in Sport and Exercise Contexts PhD
Out of School Youth Provision: An Analysis of Funding and Operational Resilience within the Sector PhD
Out of School Youth Provision: An Analysis of Funding and Operational Resilience within the Sector PhD