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Mechanical properties of tumour tissue can be used as indicators to predict the type cancer and their grade. The growth of tumour and its severity are determined by the capability of cells to multiply and migrate to the adjacent tissue. Cell mechanics and their interaction with the local tissue structure play an important role in tumour growth and cancer cell invasion. In order to understand why different type of cancer cells respond differently to various chemical and physical treatments, it is critical to gain insight on the biophysical interactions between the invading cells and the local tissue structures. Within this project we will focus on different type of breast cancers to investigate the interaction of tissue stiffness and cell mechanics at both tissue, cell and sub-celluar levels. In vitro 2D and 3D models will be established to replicate the tumour microenvironment and data derived from experimental work will further feed into modellings that can simulate the collective behaviours of cells in terms of tumour growth. The ultimate aim is to develop supplementary criteria based on the understanding of biophysical mechanisms in tumour growth and inform clinical decision.
Programme overview
Main Subject
Engineering - Mechanical
Degree
PhD
Study Level
PHD
Study Mode
On Campus
Mechanical properties of tumour tissue can be used as indicators to predict the type cancer and their grade. The growth of tumour and its severity are determined by the capability of cells to multiply and migrate to the adjacent tissue. Cell mechanics and their interaction with the local tissue structure play an important role in tumour growth and cancer cell invasion. In order to understand why different type of cancer cells respond differently to various chemical and physical treatments, it is critical to gain insight on the biophysical interactions between the invading cells and the local tissue structures. Within this project we will focus on different type of breast cancers to investigate the interaction of tissue stiffness and cell mechanics at both tissue, cell and sub-celluar levels. In vitro 2D and 3D models will be established to replicate the tumour microenvironment and data derived from experimental work will further feed into modellings that can simulate the collective behaviours of cells in terms of tumour growth. The ultimate aim is to develop supplementary criteria based on the understanding of biophysical mechanisms in tumour growth and inform clinical decision.
Admission Requirements
3.2+
6.5+
92+
Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in a related subject. A relevant Master's degree and / or experience in one or more of the following will be an advantage: Biophysics, Biotechnology, Nanotechnology, Mechanical Engineering, Materials, Biomedical Engineering.
01 Apr 2025
3 Years
Oct
Domestic
4,786
International
27,500
Scholarships
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Cell Mechanics and Tumour Growth PhD
Loughborough University, Loughborough, United Kingdom
# 100QS Subject Rankings
36 monthsProgramme duration
27,500 Tuition Fee/year
01 Apr, 2025Application Deadline
Programme overview
Main Subject
Engineering - Mechanical
Degree
PhD
Study Level
PHD
Study Mode
On Campus
Cell mechanics and their interaction with the local tissue structure play an important role in tumour growth and cancer cell invasion. In order to understand why different type of cancer cells respond differently to various chemical and physical treatments, it is critical to gain insight on the biophysical interactions between the invading cells and the local tissue structures.
Within this project we will focus on different type of breast cancers to investigate the interaction of tissue stiffness and cell mechanics at both tissue, cell and sub-celluar levels. In vitro 2D and 3D models will be established to replicate the tumour microenvironment and data derived from experimental work will further feed into modellings that can simulate the collective behaviours of cells in terms of tumour growth. The ultimate aim is to develop supplementary criteria based on the understanding of biophysical mechanisms in tumour growth and inform clinical decision.
Programme overview
Main Subject
Engineering - Mechanical
Degree
PhD
Study Level
PHD
Study Mode
On Campus
Cell mechanics and their interaction with the local tissue structure play an important role in tumour growth and cancer cell invasion. In order to understand why different type of cancer cells respond differently to various chemical and physical treatments, it is critical to gain insight on the biophysical interactions between the invading cells and the local tissue structures.
Within this project we will focus on different type of breast cancers to investigate the interaction of tissue stiffness and cell mechanics at both tissue, cell and sub-celluar levels. In vitro 2D and 3D models will be established to replicate the tumour microenvironment and data derived from experimental work will further feed into modellings that can simulate the collective behaviours of cells in terms of tumour growth. The ultimate aim is to develop supplementary criteria based on the understanding of biophysical mechanisms in tumour growth and inform clinical decision.
Admission Requirements
A relevant Master's degree and / or experience in one or more of the following will be an advantage: Biophysics, Biotechnology, Nanotechnology, Mechanical Engineering, Materials, Biomedical Engineering.
Domestic
International
Scholarships
Selecting the right scholarship can be a daunting process. With countless options available, students often find themselves overwhelmed and confused. The decision can be especially stressful for those facing financial constraints or pursuing specific academic or career goals.
To help students navigate this challenging process, we recommend the following articles:
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Looking for a fully-funded scholarship to see you into university? Find out how to boost your chances of getting one.
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Find scholarships to study abroad with our lists of international scholarships – categorized by country, by subject, and by type of student.
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Life Sciences and Medicine (6)
Adaptive and Predictive Computational Modelling of Biomaterials: A Digital Twin Framework for Next-Generation Personalised Healthcare PhD
Adaptive and Predictive Computational Modelling of Biomaterials: A Digital Twin Framework for Next-Generation Personalised Healthcare PhD
Biomarkers of Aging PhD
Biomarkers of Aging PhD
Developing Prescription Guidelines for Passive Heat Therapy PhD
Developing Prescription Guidelines for Passive Heat Therapy PhD
Does Socialised Real-Life Body Exposure Promote Body Image Positivity PhD
Does Socialised Real-Life Body Exposure Promote Body Image Positivity PhD
Energy Dissipation In Human Soft Tissue During Impacts PhD
Energy Dissipation In Human Soft Tissue During Impacts PhD
Natural Sciences (6)
Accelerated Screening and Synthesis of New Chemotherapeutic Agents for Pancreatic Cancer PhD
Accelerated Screening and Synthesis of New Chemotherapeutic Agents for Pancreatic Cancer PhD
Bespoke Organometallic Compounds for Anticancer Studies PhD
Bespoke Organometallic Compounds for Anticancer Studies PhD
Bio-based Sustainable Materials for Autonomous Thermal Management in Wearables PhD
Bio-based Sustainable Materials for Autonomous Thermal Management in Wearables PhD
Biomimmetic Catalytic Asymmetric Synthesis of the Bisorbicillinoids and Related Products PhD
Biomimmetic Catalytic Asymmetric Synthesis of the Bisorbicillinoids and Related Products PhD
Climate and Ecological Transitions Hub Studentship PhD
Climate and Ecological Transitions Hub Studentship PhD
Coherent State Methods in Spectral Asymptotics PhD
Coherent State Methods in Spectral Asymptotics PhD
Computational Modelling of Sustainable Alloys PhD
Designing Classroom Tasks To Improve Students’ Learning Of Mathematics PhD
Developing Novel Antibiofilm Coatings for Sustainable Biofilm-Free Surfaces PhD
Development of Hybrid Microcomb Sources with Topologically Protected Dark Resonances for Simultaneous Classical and Quantum PhD
Development of Novel Bicyclopentanes (BCP) Bioisosteres From Bench Stable [1.1.1]-Propellane Precursors PhD
Digital Twins for Biofilm Management PhD
Dispersionless Integrable Systems In 2+1 Dimensions PhD
Social Sciences and Management (6)
An Evaluation of Erasmus+ Sport Projects and Their Impact on EU Sport Policy Development PhD
An Evaluation of Erasmus+ Sport Projects and Their Impact on EU Sport Policy Development PhD
Climate Change, Work Design and Worker Wellbeing Phd
Climate Change, Work Design and Worker Wellbeing Phd
Communication and Social Change (CSC) Hub Studentship PhD
Communication and Social Change (CSC) Hub Studentship PhD
Enhancing Motivation in Sport and Exercise Contexts PhD
Enhancing Motivation in Sport and Exercise Contexts PhD
Out of School Youth Provision: An Analysis of Funding and Operational Resilience within the Sector PhD
Out of School Youth Provision: An Analysis of Funding and Operational Resilience within the Sector PhD